Andrew J Brown Selected Research

1- (4- (3- chlorophenylamino)- 1- methyl- 1H- pyrrolo(3,2- c)pyridin- 7- yl)- 1- morpholin- 4- ylmethanone

10/2009

Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.

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Andrew J Brown Research Topics

Disease

15	Neoplasms (Cancer) 03/2024 - 03/2007
8	Atherosclerosis 01/2016 - 02/2002
4	Prostatic Neoplasms (Prostate Cancer) 11/2019 - 09/2012
4	Cardiovascular Diseases (Cardiovascular Disease) 04/2014 - 03/2007
4	Pain (Aches) 12/2013 - 05/2007
3	Hypoxia (Hypoxemia) 03/2024 - 01/2023
3	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2012
3	Hypercholesterolemia 04/2015 - 01/2008
2	Neuroblastoma 01/2021 - 01/2010
2	Obesity 01/2021 - 12/2019
2	Neoplasm Metastasis (Metastasis) 01/2021 - 04/2015
2	Hypersensitivity (Allergy) 12/2019 - 09/2008
2	Smith-Lemli-Opitz Syndrome 10/2016 - 04/2016
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 12/2007
2	Heart Diseases (Heart Disease) 01/2015 - 07/2010
2	Fatty Liver 04/2014 - 12/2008
2	Neuralgia (Stump Neuralgia) 09/2008 - 05/2007
1	Endometrial Neoplasms (Endometrial Cancer) 03/2024
1	Methemoglobinemia 11/2023
1	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy) 11/2021
1	Insulin Resistance 01/2021
1	Colorectal Neoplasms (Colorectal Cancer) 01/2021
1	Hyperglycemia 01/2021
1	Mycoses (Diseases, Fungus) 01/2020
1	Drug-Related Side Effects and Adverse Reactions 12/2019
1	Anaphylaxis (Anaphylactic Shock) 12/2019
1	Tinea Pedis (Athlete's Foot) 01/2018
1	Liver Neoplasms (Liver Cancer) 01/2018
1	Desmosterolosis 01/2017
1	Glioblastoma (Glioblastoma Multiforme) 01/2017
1	Starvation 01/2017
1	Mevalonate Kinase Deficiency 11/2016
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 10/2015
1	Liver Diseases (Liver Disease) 04/2014
1	Non-alcoholic Fatty Liver Disease 04/2014
1	Vascular Diseases (Vascular Disease) 10/2013
1	Infections 10/2013
1	Shoulder Dislocation (Dislocation, Shoulder) 12/2012

Drug/Important Bio-Agent (IBA)

26	CholesterolIBA 03/2024 - 12/2002
9	EnzymesIBA 03/2024 - 04/2014
7	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2017 - 03/2007
6	LipidsIBA 01/2017 - 02/2002
5	SterolsIBA 03/2024 - 02/2005
5	Squalene Monooxygenase (Squalene Epoxidase)IBA 03/2024 - 01/2019
4	SqualeneIBA 01/2023 - 04/2014
4	OxysterolsIBA 01/2021 - 04/2002
3	LigandsIBA 01/2021 - 09/2006
3	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2021 - 06/2013
2	Oxygen (Dioxygen)IBA 03/2024 - 01/2023
2	Oxidoreductases (Dehydrogenase)IBA 01/2017 - 06/2013
2	Sterol Regulatory Element Binding ProteinsIBA 01/2017 - 03/2007
2	LDL Lipoproteins (beta Lipoproteins)IBA 01/2017 - 02/2002
2	Lipoproteins (Lipoprotein)IBA 01/2017 - 12/2002
2	DesmosterolIBA 01/2017 - 04/2014
2	lysophosphatidylinositolIBA 12/2013 - 04/2011
2	Proteins (Proteins, Gene)FDA Link 06/2013 - 02/2002
2	Phosphotransferases (Kinase)IBA 10/2011 - 01/2011
1	Methylene Blue (Methylthioninium Chloride)FDA Link 11/2023
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2023
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2023
1	Protein Isoforms (Isoforms)IBA 11/2021
1	CateninsIBA 01/2021
1	OrexinsIBA 01/2021
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2021
1	NestinIBA 01/2021
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 01/2021
1	GlycopeptidesIBA 12/2019
1	Peptides (Polypeptides)IBA 12/2019
1	Vancomycin FDA LinkGeneric 12/2019
1	Histamine (Histamine Dihydrochloride)FDA Link 12/2019
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2019
1	SecretagoguesIBA 12/2019
1	Androgen Receptors (Androgen Receptor)IBA 11/2019
1	Antifungal AgentsIBA 01/2018
1	CyclodextrinsIBA 01/2017
1	site 1 membrane-bound transcription factor peptidaseIBA 01/2017
1	PF-429242IBA 01/2017
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2017
1	SteroidsIBA 01/2017
1	Terpenes (Terpenoids)IBA 01/2017
1	rab GTP-Binding ProteinsIBA 11/2016
1	Mevalonic Acid (Mevalonate)IBA 11/2016
1	Methamphetamine (Desoxyn)FDA LinkGeneric 12/2015
1	Sirolimus (Rapamycin)FDA Link 10/2015
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 10/2015
1	Adenosine Triphosphate (ATP)IBA 07/2015
1	Caveolin 1IBA 04/2015
1	AndrogensIBA 04/2015
1	Liposomes (Liposome)IBA 03/2015
1	Vitamin D FDA LinkGeneric 04/2014
1	ElementsIBA 01/2014
1	RE1-silencing transcription factorIBA 01/2014
1	GTP-Binding Proteins (G-Protein)IBA 12/2013
1	3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)IBA 06/2013
1	Capsules (Microcapsules)IBA 12/2012
1	Green Fluorescent ProteinsIBA 10/2012
1	Apolipoproteins E (ApoE)IBA 10/2012

Therapy/Procedure

7	Therapeutics 01/2017 - 12/2002
1	Ambulatory Care (Outpatient Care) 11/2023
1	Intravenous Infusions 12/2019